编者按

近日，多部委印发了《关于进一步加强科研诚信建设的若干意见》，对进一步推进科研诚信制度化建设等方面做出部署。就在近期，科技部将会同40余部门联合发布《关于对科研领域相关失信责任主体实施联合惩戒的备忘录》。科研诚信是科技创新的基石。近年来，我国科研诚信建设在工作机制、制度规范、教育引导、监督惩戒等方面取得了显著成效，但整体上仍存在短板和薄弱环节，违背科研诚信要求的行为时有发生。为全面贯彻党的十九大精神，培育和践行社会主义核心价值观，弘扬科学精神，倡导创新文化，加快建设创新型国家，现就进一步加强科研诚信建设、营造诚实守信的良好科研环境提出以下意见。建立终身追究制度，依法依规对严重违背科研诚信要求行为实行终身追究，鼓励对违背科研诚信要求的行为进行负责任实名举报；2018年12月6日，总理也强调严查违背科研道德和伦理的不端行为....

RetractionWatch

原苏州大学（现温州医科大学）王志伟教授的27篇论文（第一作者12篇，第二作者5篇，其余作者 10篇）因学术不端行为被多种知名学术期刊撤稿。这27篇肿瘤学领域的学术论文主要发表于2006年至2011年之间，被Cancer Research，International Journal of Cancer, Cancer等期刊撤稿。撤稿原因是论文里图片重复编排（镜像翻转、魔法拼图，重复使用图片），甚至图片直接复制了以往已经发表的论文（一图多用）。论文的第一作者是在美国韦恩州立大学医学院学习/工作期间的王志伟，而通讯作者则是曾经的“抗癌英雄” Fazlul H. Sarkar教授（在Retraction Watch网站上，Fazlul H. Sarkar被撤稿论文排名前十位）。王志伟教授在苏州大学5年期间（2013年-2018年）所发表的40余篇论文，多篇论文也存在图片重复编排使用，涉嫌造假（后续进一步爆料）。现在RetractionWatch分批次报道。同时RetractionWatch@温州医科大学等机构，进行后续的处理。

作者介绍

王志伟 教授，博士生导师

教育/工作经历：

1989年-1994年 蚌埠医学院 临床医学专业 学士；

1994年-1998年 蚌埠医学院 助教；

1998年-2001年 上海交通大学医学院 细胞生物学专业 硕士；

2001年-2002年 上海交通大学医学院 助教；

2002年-2006年 美国韦恩州立大学医学院 病理学专业 博士；

2007年-2011年 美国韦恩州立大学医学院 博士后/研究助理；

2011年-2013年 美国哈佛大学医学院 讲师 ；

2013年-2018年5月 苏州大学唐仲英血液学研究中心 教授 ；

2018年6月-至今 温州医科大学附属第二医院科研中心 教授 ；

研究领域：

细胞信号传导和肿瘤发生机制,自然化合物抗癌的机制。

主持基金项目：

SPOP参与胰腺癌细胞生长和耐药的机制研究（国家自然科学基金面上项目，苏州大学，25万）

调控Set8表达增加胰腺癌化疗药敏感性的机制研究（国家自然科学基金面上项目，苏州大学，57万）

1.Cancer Res：Epidermal Growth Factor Receptor-Related Protein Inhibits Cell Growth and Invasion in Pancreatic Cancer

本文已根据编辑的要求撤回。在韦恩州立大学（密歇根州底特律市）进行机构审查后，几位作者的主要隶属关系，确定了实验结论无法得到数据支持。

图2C和D

在图2C和D中，复制，重新排序，重新标记和操作多个Western印迹条带;

图4

在图4中，操纵相同的图像并重新标记以代表来自不同实验条件的结果（“HPAC Control”和“HPAC ERRP”）;

图5C

如图5C和6所示，复制，操作和重新标记相同的Western印迹条带以表示Notch1（图5C）和MMP-9（图6）。

图6

由于这些调查结果，该机构建议撤回，并在内部审查后，编辑同意这一建议。

此撤回通知的副本已发送至11位作者中的10位的最后已知电子邮件地址。两位作者（R. Mohammad和J.L. Abbruzzese）同意撤回;八位作者（Z。Wang，R。Sengupta，S。Banerjee，Y。Li，K.M.W。Rahman，A。Aboukameel，A.P.N。Majumdar和F.H. Sarkar）没有回应;无法找到剩下的作者（Y. Zhang）。

撤稿链接：

http://cancerres.aacrjournals.org/content/78/18/5474.full-text.pdf

2.Down-regulation of notch-1 inhibits invasion by inactivation of nuclear factor-kappaB, vascular endothelial growth factor, and matrix metalloproteinase-9 in pancreatic cancer cells

本文已根据编辑的要求撤回。 在韦恩州立大学（密歇根州底特律市）进行机构审查后，作为几位作者的主要隶属关系，确定了作者伪造和/或伪造数据。 具体地，图2C中的Western印迹数据被不适当地切割，粘贴和掩蔽。 另外，确定图4A的顶部和底部的部分与也正在缩回的另一个出版物（ Mol Cancer Ther 2006;5:483–93）中的部分相同。 由于这些调查结果，该机构建议撤回，并在内部审查后，编辑同意这一建议。

此撤回通知的副本已发送至七位作者中六位。 一位作者（J.L. Abbruzzese）同意撤回; 五位作者（Z。Wang，S。Banerjee，Y。Li，N.V。Adsay和F.H. Sarkar）没有回应; 剩下的一位作者（D. Kong）无法找到。

撤稿链接：

http://cancerres.aacrjournals.org/content/78/18/5469

3.Down-regulation of Forkhead Box M1 Tranion Factor Leads to the Inhibition of Invasion and Angiogenesis of Pancreatic Cance

本文已根据编辑的要求撤回。在韦恩州立大学（密歇根州底特律市）的机构审查（几位作者的主要隶属关系）之后，确定文章包括多个数据伪造和/或制造实例，包括不适当的剪切/粘贴和图像处理特别是图4C中的多个Western印迹条带，图1D中的FoxM1 Western印迹条带，和图5B中的MMP-9和uPAR条带。另外，图5B中的uPAR条带在先前公开的文章（Mol Cancer Ther 2006;5:483–93）中从图5中的细胞周期蛋白D1 Western印迹条带复制并重命名。由于这些调查结果，该机构建议撤回，并在内部审查后，编辑同意这一建议。

此撤回通知的副本已发送至五位作者中的四位。四位作者（Z。Wang，S。Banerjee，Y。Li和F.H. Sarkar）没有回应;无法找到一位作者（D. Kong）。

原文链接：

http://cancerres.aacrjournals.org/content/78/18/5470

27篇撤稿文章列表：

1. Retraction: Down-regulation of Platelet-Derived Growth Factor-D Inhibits Cell Growth and Angiogenesis through Inactivation of Notch-1 and Nuclear Factor-κB Signaling.Zhiwei Wang, Dejuan Kong, Sanjeev Banerjee, Yiwei Li, N. Volkan Adsay, James Abbruzzese, Fazlul H. SarkarCancer Res. 2018 Sep 15;78(18):5469.

2. Retraction: Down-regulation of Forkhead Box M1 Tranion Factor Leads to the Inhibition of Invasion and Angiogenesis of Pancreatic Cancer Cells. Zhiwei Wang, Sanjeev Banerjee, Dejuan Kong, Yiwei Li, Fazlul H. Sarkar Cancer Res. 2018 Sep 15;78(18):5470.

3. Retraction: Epidermal Growth Factor Receptor-Related Protein Inhibits Cell Growth and Invasion in Pancreatic Cancer.Zhiwei Wang, Radha Sengupta, Sanjeev Banerjee, Yiwei Li, Yuxiang Zhang, K.M. Wahidur Rahman, Amro Aboukameel, Ramzi Mohammad, Adhip P.N. Majumdar, James L. Abbruzzese, Fazlul H. Sarkar

Cancer Res. 2018 Sep 15;78(18):5474.

4. Retraction:Down-regulation of Notch-1 Inhibits Invasion by Inactivation of Nuclear Factor-κB, Vascular Endothelial Growth Factor, and Matrix Metalloproteinase-9 in Pancreatic Cancer Cells.Zhiwei Wang, Sanjeev Banerjee, Yiwei Li, K.M. Wahidur Rahman, Yuxiang Zhang, Fazlul H. SarkarCancer Res. 2018 Sep 15;78(18):5476.

5. Retraction:Inhibition of nuclear factor kappab activity by genistein is mediated via Notch-1 signaling pathway in pancreatic cancer cells.Zhiwei Wang, Yuxiang Zhang, Sanjeev Banerjee, Yiwei Li, Fazlul H. SarkarInt J Cancer. 2016 Nov 1;139(9):2145.

6. Retraction: TW-37, a small-molecule inhibitor of Bcl-2, inhibits cell growth and invasion in pancreatic cancer.Zhiwei Wang, Wen Song, Amro Aboukameel, Mussop Mohammad, Guoping Wang, Sanjeev Banerjee, Dejuan Kong, Shaomeng Wang, Fazlul H. Sarkar, Ramzi M. MohammadInt J Cancer. 2016 Nov 1;139(9):2146.

7. Retraction: Notch-1 down-regulation by curcumin is associated with the inhibition of cell growth and the induction of apoptosis in pancreatic cancer cells.Zhiwei Wang, Yuxiang Zhang, Sanjeev Banerjee, Yiwei Li, Fazlul H. Sarkar

Cancer. 2016 Oct 15;122(20):3247.

8. Retraction: Downregulation of Notch-1 Contributes to Cell Growth Inhibition and Apoptosis in Pancreatic Cancer Cells.Zhiwei Wang, Yuxiang Zhang, Yiwei Li, Sanjeev Banerjee, Joshua Liao and Fazlul H. SarkarMol Cancer Ther. 2018 Oct;17(10):2268.

9. Retraction: Activated K-Ras and INK4a/Arf Deficiency Promote Aggressiveness of Pancreatic Cancer by Induction of EMT Consistent With Cancer Stem Cell Phenotype.Zhiwei Wang, Shadan Ali, Sanjeev Banerjee, Bin Bao, Yiwei Li, Asfar S. Azmi, Murray Korc, Fazlul H. SarkarJ Cell Physiol. 2016 Oct;231(10):2304.

10. Retraction: Down-regulation of Notch-1 and Jagged-1 inhibits prostate cancer cell growth, migration and invasion, and induces apoptosis via inactivation of Akt, mTOR, and NF-κB signaling pathwaysZhiwei Wang, Yiwei Li, Sanjeev Banerjee, Dejuan Kong, Aamir Ahmad, Veronique Nogueira, Nissim Hay, Fazlul H SarkarJ Cell Biochem. 2016 Aug;117(8):1960.

11. Retraction: Down-regulation of Notch-1 is associated with Akt and FoxM1 in inducing cell growth inhibition and apoptosis in prostate cancer cells.

Zhiwei Wang, Yiwei Li, Aamir Ahmad, Sanjeev Banerjee, Asfar S. Azmi, Dejuan Kong, Christine Wojewoda, Lucio Miele, Fazlul H. SarkarJ Cell Biochem. 2016 Aug;117(8):1962.

12. Retraction: Activated K-ras and INK4a/Arf Deficiency Cooperate During the Development of Pancreatic Cancer by Activation of Notch and NF-κB Signaling Pathways.Zhiwei Wang, Sanjeev Banerjee, Aamir Ahmad, Yiwei Li, Asfar S. Azmi, Jason R. Gunn, Dejuan Kong, Bin Bao, Shadan Ali, Jiankun Gao, Ramzi M. Mohammad, Lucio Miele, Murray Korc, Fazlul H. Sarkar

PLoS One. 2018 Oct 2;13(10):e0205289.

13. Retraction: 3,3'-Diindolylmethane Enhances Chemosensitivity of Multiple Chemotherapeutic Agents in Pancreatic Cancer.Sanjeev Banerjee, Zhiwei Wang, Dejuan Kong, Fazlul H. SarkarCancer Res. 2018 Sep 15;78(18):5467.

14. Retraction: Notch-1 induces Epithelial-mesenchymal transition consistent with cancer stem cell phenotype in pancreatic cancer cells.Bin Bao, Zhiwei Wang, Shadan Ali, Dejuan Kong, Yiwei Li, Aamir Ahmad, Sanjeev Banerjee, Asfar S. Azmi, Lucio Miele, Fazlul H. SarkarCancer Lett. 2018 Jun 1;423:153.

15. Retraction: Platelet-derived growth factor-D contributes to aggressiveness of breast cancer cells by up-regulating Notch and NF-κB signaling pathways.Ahmad A, Wang Z, Kong D, Ali R, Ali S, Banerjee S, Sarkar FH.Breast Cancer Res Treat. 2016 Aug;158(3):605.

16. Retraction: FoxM1 down-regulation leads to inhibition of proliferation, migration and invasion of breast cancer cells through the modulation of extra-cellular matrix degrading factors.Aamir Ahmad, Zhiwei Wang, Dejuan Kong, Shadan Ali, Yiwei Li, Sanjeev Banerjee, Raza Ali, Fazlul H. SarkarBreast Cancer Res Treat.2016 Aug;158(3):607.

17. Retraction: Over-expression of FoxM1 leads to epithelial-mesenchymal transition and cancer stem cell phenotype in pancreatic cancer cells.Bin Bao, Zhiwei Wang, Shadan Ali, Dejuan Kong, Sanjeev Banerjee, Aamir Ahmad, Yiwei Li, Asfar S. Azmi, Lucio Miele, Fazlul H. SarkarJ Cell Biochem.2016 Aug;117(8):1963.

18. Retraction:Antitumor Activity of Gemcitabine and Oxaliplatin Is Augmented by Thymoquinone in Pancreatic Cancer.Sanjeev Banerjee, Ahmed O. Kaseb, Zhiwei Wang, Deujan Kong, Mussop Mohammad, Subhash Padhye, Fazlul H. Sarkar, Ramzi M. MohammadCancer Res.2018 Sep 15;78(18):5468.

19. Retraction:Inhibition of Angiogenesis and Invasion by 3,3'-Diindolylmethane Is Mediated by the Nuclear Factor-κB Downstream Target Genes MMP-9 and uPA that Regulated Bioavailability of Vascular Endothelial Growth Factor in Prostate Cancer.Dejuan Kong, Yiwei Li, Zhiwei Wang, Sanjeev Banerjee, Fazlul H. Sarkar

Cancer Res. 2018 Sep 15;78(18):5471.

20. Retraction:Antitumor Activity of Epidermal Growth Factor Receptor-Related Protein Is Mediated by Inactivation of ErbB Receptors and Nuclear Factor-κB in Pancreatic Cancer.Yuxiang Zhang, Sanjeev Banerjee, Zhiwei Wang, Hu Xu, Liyue Zhang, Ramzi Mohammad, Amro Aboukameel, Nazmi V. Adsay, Mingxin Che, James L. Abbruzzese, Adhip P.N. Majumdar, Fazlul H. SarkarCancer Res. 2018 Sep 15;78(18):5477.

21. Retraction: In vitro and in vivo molecular evidence of genistein action in augmenting the efficacy of cisplatin in pancreatic cancer.Sanjeev Banerjee, Yuxiang Zhang, Zhiwei Wang, Mingxin Che, Paul J Chiao, James L Abbruzzese, Fazlul H. SarkarInt J Cancer. 2016 Nov 1;139(9):2145-6.

22. Retraction: Down-regulation of uPA and uPAR by 3,3'-diindolylmethane contributes to the inhibition of cell growth and migration of breast cancer cells

Aamir Ahmad, Dejuan Kong, Zhiwei Wang, Sanila H. Sarkar, Sanjeev Banerjee, Fazlul H. SarkarJ Cell Biochem. 2016 Aug;117(8):1959.

23. Retracted:Restoring sensitivity to oxaliplatin by a novel approach in gemcitabine‐resistant pancreatic cancer cells in vitro and in vivo.Sanjeev Banerjee, Dejuan Kong, Asfar S. Azmi, Zhiwei Wang, Aamir Ahmad, Seema Sethi, Fazlul H. SarkarInt J Cancer.2016 Nov 1;139(9):2146.

24. Retraction: Therapeutic intervention of experimental breast cancer bone metastasis by indole-3-carbinol in SCID-human mouse model.KM Wahidur Rahman, Fazlul H. Sarkar, Sanjeev Banerjee, Zhiwei Wang, Dezhong J. Liao, Xin Hong and Nurul H. SarkarMol Cancer Ther. 2018 Oct;17(10):2267.

25. Retraction: Anti-Tumor Activity of a Novel Compound-CDF Is Mediated by Regulating miR-21, miR-200, and PTEN in Pancreatic Cancer.Bin Bao, Shadan Ali, Dejuan Kong, Sanila H. Sarkar, Zhiwei Wang, Sanjeev Banerjee, Amro Aboukameel, Subhash Padhye, Philip A. Philip, Fazlul H. SarkarPLoS One.2018 Oct 2;13(10):e0205300.

26. Retraction: Down-regulation of Androgen Receptor by 3,3'-Diindolylmethane Contributes to Inhibition of Cell Proliferation and Induction of Apoptosis in Both Hormone-Sensitive LNCaP and Insensitive C4-2B Prostate Cancer Cells.Mohammad M.R. Bhuiyan, Yiwei Li, Sanjeev Banerjee, Fakhara Ahmed, Zhiwei Wang, Shadan Ali, Fazlul H. SarkarCancer Res.2018 Sep 15;78(18):5473.

27. Retraction: Gemcitabine Sensitivity Can Be Induced in Pancreatic Cancer Cells through Modulation of miR-200 and miR-21 Expression by Curcumin or Its Analogue CDF.Shadan Ali, Aamir Ahmad, Sanjeev Banerjee, Subhash Padhye, Kristin Dominiak, Jacqueline M. Schaffert, Zhiwei Wang, Philip A. Philip, Fazlul H. SarkarCancer Res. 2018 Sep 15;78(18):5466.

来源：RetractionWatch

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